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Saturday, August 8, 2020 | History

5 edition of Membrane transporters as drug targets found in the catalog.

Membrane transporters as drug targets

Membrane transporters as drug targets

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  • 20 Currently reading

Published by Kluwer Academic/Plenum Publishers in New York .
Written in English

    Subjects:
  • Drug targeting,
  • Drugs -- Physiological transport,
  • Carrier proteins,
  • Drug carriers (Pharmacy)

  • Edition Notes

    Includes bibliographical references and index

    Statementedited by Gordon L. Amidon and Wolfgang Sadée
    SeriesPharmaceutical biotechnology -- v. 12
    ContributionsAmidon, Gordon L, Sadee, Wolfgang, 1942-
    Classifications
    LC ClassificationsRM301.65 .M45 1999
    The Physical Object
    Paginationxxv, 528 p. :
    Number of Pages528
    ID Numbers
    Open LibraryOL18097170M
    ISBN 100306460947
    LC Control Number99037278

    For this reason, during the last two decades, plasma membrane transporters have been envisaged as targets for the development of strategies aimed at sensitizing cancer cells to chemotherapy, either by increasing the uptake or reducing the export of antitumor agents by modulating the expression/function of SLC and ABC proteins, : Jose J.G. Marin, Rocio I.R. Macias, Candela Cives-Losada, Ana Peleteiro-Vigil, Elisa Herraez, Elisa. The role that membrane transporter proteins play in drug resistance in various species of Candida, Aspergillus and Cryptococcus will be address in more detail, as will be their importance as selective drug targets in the design of novel antifungal agent s.

    Transporters play a significant role in a drug's clinical efficacy and safety. Eurofins Discovery, through the expertise of Eurofins Cerep and Eurofins Panlabs, has developed robust transporter uptake and inhibition assays to allow quick and cost-effective screening of new molecular entities (NMEs) for their interactions with these transporters. The biological process is a cycled network, and the membrane protein is a vital hub in the network since most drugs achieve the therapeutic effect via interacting with the membrane protein. In this review, typical membrane protein targets are described, including GPCRs, transporters and ion channels.

      Types of Membrane Transporters 8 genes in the human genome (7% of the total number of genes) code for transporters or transporter-related proteins. In considering the transport of drugs, pharmacologists generally focus on transporters from two major superfamilies, ABC (ATP binding cassette) and SLC (solute carrier) transporters Most ABC. bases and the drugs that mimic them, and it is important to understand their underlying molecular basis. Recent advances in molecular biology techniques have clarified the molecular e-mail: [email protected] Current Topics Membrane Transporters as Targets for the Development of Drugs and Therapeutic Strategies Review.


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Membrane transporters as drug targets Download PDF EPUB FB2

Membrane Transporters as Drug Targets (Pharmaceutical Biotechnology Book 12) - Kindle edition by Amidon, Gordon L., Sadée, Wolfgang. Download it once and read it on your Kindle device Manufacturer: Springer.

Membrane Transporters as Drug Targets (Pharmaceutical Biotechnology (12)): Medicine & Health Science Books @ mat: Hardcover. Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters.

There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body. As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes.

Pharmacodynamics: Transporters as Drug Targets. Membrane transporters are the targets of many clinically used drugs. For example, neurotransmitter transporters are the targets for drugs used in the treatment of neuropsychia-tric disorders (Amara and Sonders, ; Inoue et al., ).

SERT (SLC6A4) is a target for a major class of anti-File Size: 2MB. Membrane Transporters as Drug Targets Edited by Gordon L. Amidon University of Michigan Ann Arbor, Michigan and Wolfgang Sadee University of California, San Francisco San Francisco, California Kluwer Academic /Plenum Publishers New York, Boston, Dordrecht, London, Moscow.

overview on the topic of this book, focusing on transporters as drug targets. Available Transporter Classifications As a consequence of the significance of the transport process for every living organism, already numerous classification schemes for membrane transport pro-teins of.

DrugBank contains four types of drug-protein interactions. Target: A protein, macromolecule, nucleic acid, or small molecule to which a given drug binds, resulting in an alteration of the normal function of the bound molecule anda desirable therapeutic targets are most commonly proteins such as enzymes, ion channels, and receptors.

Enzyme: A protein which catalyzes chemical Cited by: 2. Membrane proteins continue to be prime drug targets because they perform essential processes in the cell including controlling the flow of information and materials between cells and mediating activities like hormone action.

SLC transporters as targets of drugs. Many SLC transporters have been identified as druggable — that is, they contribute to a disease phenotype and can be modulated by drugs More information can be found in Table 1 and Table by: Title:Membrane Transporters as Determinants of the Pharmacology of Platinum Anticancer Drugs VOLUME: 12 ISSUE: 8 Author(s):Johnson J.

Liu, Jun Lu and Mark J. McKeage Affiliation:Department of Pharmacology and Clinical Pharmacology, and the Auckland Cancer Society Research Centre, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, 85 Park Road. For example, transporters can serve as drug targets or as a mechanism to facilitate drug delivery to cells and tissues.

Recently exploited drug transporter targets include neurotransmitter transporters (SLC6 family), intestinal bile acid transporters (SLC10 family) and cation-Cl Cited by: Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes.

Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. Bingham • S. Napier: Overview: Transporters as Targets for Drug Discovery.

Sylte • A.W. Ravna • G. Sager • S.G. Dahl: Membrane Transporters: Structure. Current therapeutic drugs act on four main types of molecular targets: enzymes, receptors, ion channels and transporters, among which a major part (%) are membrane proteins.

This review discusses the molecular structures and potential impact of membrane transporter proteins on new drug discovery. The three-dimensional (3D) molecular structure of a protein contains information about the. These transporters modulate drug absorption by pumping the drugs out of the intestine or keeping them in the intestinal lumen.

Transporters can bring drugs into the liver where they can be metabolized. In the kidneys, transporters can actively eliminate drugs so that they are excreted in the urine.

Current therapeutic drugs act on four main types of molecular targets: enzymes, receptors, ion channelsand transporters, among which a major part (60–70%) are membrane proteins. This review discussesthe molecular structures and potential impact of membrane transporter proteins on new drug by: 5.

Membrane transporters as drug targets. [Gordon L Amidon; Wolfgang Sadée;] -- Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of. Membrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profiles of drugs.

This presents several key questions for drug development, including which Cited by: As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets.

Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology.

The text covers all transporter families with known or suspected importance as. Overview of Membrane Transport.- Classification of Membrane Transporters.- Drug Transport and Targeting.- The Molecular Basis for Hepatobiliary Transport of Organic Cations and Organic Anions.- Affinity of Drugs to the Different Renal Transporters for Organic Anions and Organic Cations.- Drug Disposition and Targeting.- The Mammalian Facilitative Glucose Transporter (GLUT) Familycation transporters (OCTs) are low-affinity transporters of monoamines,2,3) and the inhibition of OCTs as well as the high-affinity monoamine transporters including the serotonin To whom correspondence should be addressed.e-mail: [email protected] Current Topics Membrane Transporters as Targets Cited by: 4.

Solute carrier (SLC) transporters — a family of more than membrane-bound proteins that facilitate the transport of a wide array of substrates across Cited by: